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Reducing calorie intake slows aging and significantly delays the onset of age-related problems such as cardiovascular disease, diabetes, cancer, and brain atrophy in monkeys, a new study says.
It's likely that reducing caloric intake would have the same positive effects in people, researchers report in the journal Science.
During the 20-year study, 50% of the monkeys allowed to eat freely have survived, while 80% that ate the same foods but with 30% fewer calories remain alive, University of Wisconsin-Madison scientists say.
"This is the largest and most highly controlled study showing the beneficial effects of calorie restriction on disease and survival in a primate species," study author Ricki J. Colman, PhD, of the Wisconsin National Primate Research Center, tells WebMD. "We believe that what works in primates will work in humans because primates are so closely related to humans. This has allowed us to understand the mechanisms of the aging process."
The message for all human adults, and especially for younger people, is to reduce caloric intake permanently and you'll likely "experience the same benefits," Colman tells WebMD.
Calorie-Restricted Diet Increases Survival
The research started with 30 rhesus macaques in 1989 to chart the health effects of a calorie-restricted diet and expanded in 1994 with the addition of 46 more.
All of the animals were enrolled as adults, at ages from 7 to 14. The researchers write that of the original 76 animals in the study, 37% of the control monkeys died of age-related causes, compared to only 13% on a calorie-restricted diet.
Rhesus macaques have an average life span of 27 years in captivity, and the oldest one still in the study is 29.
Looking at overall animal health, the calorie-restricted diet leads to longer life span and improved quality of life in old age, Richard Weindruch, PhD, a professor of medicine at the University of Wisconsin-Madison School of Medicine and Public Health and co-author of the study, says in a news release.
"There is a major effect of caloric restriction in increasing survival if you look at deaths due to the diseases of aging," he says.
According to the study, the incidence of cancerous tumors and cardiovascular disease in the monkeys on a restricted diet was half that seen in the animals that were allowed to eat freely.
Although diabetes or prediabetes was seen in 42% of the monkeys that could eat all they want, it has yet to be seen in any animal on the calorie-restricted diet, the researchers say, adding that they consider this result remarkable.
"So far, we've seen the complete prevention of diabetes," Weindruch says.
减少卡路里摄取量显着减缓老化和延误的发生与年龄有关的问题，如心血管疾病，糖尿病，癌症和脑萎缩的猴子，一项新的研究说。
很可能是减少热量摄入也具有同样的积极效果的人，研究人员在科学杂志。
在20年的研究中， 50 %的猴子吃允许自由存活下来，而80 %的人吃同样的食物，但热量少30 %仍然活着，威斯康星大学麦迪逊分校的科学家说。
这是最大的和最高度的对照研究显示的有利影响的热量限制的疾病和生存的灵长类物种， "研究作者Ricki学者科尔曼博士的威斯康星国家灵长类动物研究中心，告诉讯。 "我们相信，是什么在起作用将工作在灵长类动物，因为人类的灵长类动物是如此密切相关的人类。这使我们能够理解的机制老化过程。 "
该消息对所有人权的成年人，尤其是年轻的人，是减少热量摄入永久和您可能会"的经验同样的福利， "科尔曼告诉讯。
限制热量饮食增加生存
这项研究始于30猕猴，以图在1989年对健康影响的限制热量饮食和扩大1994年增加了46个以上。
所有的动物被录取为成人，年龄在7日至14日。研究人员撰写原始76动物研究中， 37 %的控制猴子死于与年龄有关的原因，相比之下，只有13 %的限制热量饮食。
猕猴平均寿命为27年囚禁，以及最古老的一个仍然在研究29 .
从整体动物健康，限制热量饮食会导致较长的寿命和生活质量的提高在年老，理查德Weindruch ,博士，医学教授在威斯康星大学麦迪逊分校医学院和公共卫生与合作作者的研究说，在一个新闻发布会。
"有重大影响的热量限制在提高生存如果你看看死于疾病的老龄化， "他说。
根据这项研究，在肿瘤的发病率和心血管疾病中的猴子对饮食是有限制的一半，看到的动物，被允许自由进食。
虽然糖尿病或前期被认为在42 %的猴子，可以吃所有他们想要的，但它尚未看到任何动物的限制热量饮食研究人员说，补充说，他们认为这样的结果显着。
"到目前为止，我们已经看到了完整的预防糖尿病， " Weindruch说。
